Oxymetazoline — Membership Pricing

Related medications

Other medications associated with the same conditions in this catalog.

Also listed for Rhinosinusitis (Symptomatic)

• Fluticasone Nasal
• Fluticasone nasal 50 mcg
• Oxymetazoline 0.05% nasal (short-term)

About Oxymetazoline

Oxymetazoline is primarily used to relieve nasal congestion caused by the common cold, hay fever (allergic rhinitis), and other upper respiratory allergies. It helps you breathe easier by clearing up stuffiness, making it a go-to for many seeking quick relief from a blocked nose. ### How Oxymetazoline Works Its Magic

This medication belongs to a class of drugs called decongestants. When sprayed into the nose, oxymetazoline works by narrowing the small blood vessels in the nasal passages. This reduction in blood flow decreases swelling and mucus production, effectively opening up your airways and making it easier to breathe. It's known for providing fast and effective relief, often within minutes, and its effects can last for several hours. However, it's crucial to use oxymetazoline only for short periods, typically no more than three days, to avoid a condition called "rebound congestion" or rhinitis medicamentosa, where congestion can worsen if the spray is used too frequently or for too long. ### Understanding Typical Costs

As an over-the-counter (OTC) medication, oxymetazoline nasal sprays are widely available at pharmacies and grocery stores. A typical bottle can range from $5 to $15, depending on the brand, size, and where you purchase it. While this might seem affordable for a single purchase, frequent use or multiple family members needing relief can add up over time. For those managing chronic allergies or frequent colds, these costs can become a recurring expense that impacts your household budget. We understand that even seemingly inexpensive medications can

The information above is for educational purposes only and does not constitute medical advice. Consult your healthcare provider before making medication decisions.

What Oxymetazoline is approved for (FDA label)

Oxymetazoline Hydrochloride Cream, 1% is indicated for the topical treatment of persistent facial erythema associated with rosacea in adults. Oxymetazoline Hydrochloride Cream is an alpha 1A adrenoceptor agonist indicated for the topical treatment of persistent facial erythema associated with rosacea in adults. ( 1 )

Source: Read the full FDA label on DailyMed. Label effective date: July 13, 2026.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Dosage forms and strengths for Oxymetazoline (FDA label)

Oxymetazoline Hydrochloride Cream, 1% is a white to off-white cream. Each gram of cream contains 10 mg (1%) oxymetazoline hydrochloride, equivalent to 8.8 mg (0.88%) of oxymetazoline free base. Cream, 1%. Each gram of cream contains 10 mg (1%) oxymetazoline hydrochloride, equivalent to 8.8 mg (0.88%) of oxymetazoline free base. ( 3 )

Source: FDA prescribing information (DailyMed). Set ID: 34298db6-647d-480d-88a8-dc53258a5164. SPL document ID: a49cde4c-e484-4cb9-85c2-35ba41690f35. Label effective date: July 13, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Adverse reactions for Oxymetazoline (FDA label)

Most common adverse reactions (incidence ≥ 1%) are application site dermatitis, worsening inflammatory lesions of rosacea, application site pruritis, application site erythema, and application site pain. ( 6.1 ) To report SUSPECTED ADVERSE REACTIONS, contact Mayne Pharma at 1-844-825-8500 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. 6.1 Clinical Studies Experience Because clinical trials are conducted under varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. A total of 489 subjects with persistent facial erythema associated with rosacea were treated with Oxymetazoline Hydrochloride Cream once daily for 4 weeks in 3 controlled clinical trials.

Source: FDA prescribing information (DailyMed). Set ID: 34298db6-647d-480d-88a8-dc53258a5164. SPL document ID: a49cde4c-e484-4cb9-85c2-35ba41690f35. Label effective date: July 13, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Contraindications for Oxymetazoline (FDA label)

None. None. ( 4 )

Source: FDA prescribing information (DailyMed). Set ID: 34298db6-647d-480d-88a8-dc53258a5164. SPL document ID: a49cde4c-e484-4cb9-85c2-35ba41690f35. Label effective date: July 13, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Warnings and precautions for Oxymetazoline (FDA label)

Alpha-adrenergic agonists as a class may impact blood pressure. Advise patients with cardiovascular disease, orthostatic hypotension, and/or uncontrolled hypertension or hypotension to seek medical care if their condition worsens. ( 5.1 ) Use with caution in patients with cerebral or coronary insufficiency, Raynaud's phenomenon, thromboangiitis obliterans, scleroderma, or Sjögren's syndrome and advise patients to seek medical care if signs and symptoms of potentiation of vascular insufficiency develop. ( 5.2 ) Advise patients to seek immediate medical care if signs and symptoms of acute narrow-angle glaucoma develop. ( 5.3 ) 5.1 Potential Impacts on Cardiovascular Disease Alpha-adrenergic agonists may impact blood pressure. Oxymetazoline Hydrochloride Cream should be used with caution in patients with severe or unstable or uncontrolled cardiovascular disease, orthostatic hypotension, and uncontrolled hypertension or hypotension.

Source: FDA prescribing information (DailyMed). Set ID: 34298db6-647d-480d-88a8-dc53258a5164. SPL document ID: a49cde4c-e484-4cb9-85c2-35ba41690f35. Label effective date: July 13, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Drug interactions for Oxymetazoline (FDA label)

7.1 Anti-hypertensives/Cardiac Glycosides Alpha-adrenergic agonists, as a class, may impact blood pressure. Caution in using drugs such as beta-blockers, anti-hypertensives and/or cardiac glycosides is advised. Caution should also be exercised in patients receiving alpha 1 adrenergic receptor antagonists such as in the treatment of cardiovascular disease, benign prostatic hypertrophy, or Raynaud's disease. 7.2 Monoamine Oxidase Inhibitors Caution is advised in patients taking MAO inhibitors which can affect the metabolism and uptake of circulating amines.

Source: FDA prescribing information (DailyMed). Set ID: 34298db6-647d-480d-88a8-dc53258a5164. SPL document ID: a49cde4c-e484-4cb9-85c2-35ba41690f35. Label effective date: July 13, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.