Danazol — Discount Pricing

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About Danazol

Danazol is a synthetic steroid medication used to manage specific, often challenging, health conditions. Understanding its purpose and how it works is key for those prescribed it. At TheDrugClub, we believe access to necessary medications shouldn't break the bank. Discover how our membership can help you find significant savings on your danazol prescription.

Danazol is a unique synthetic steroid medication often prescribed for conditions that significantly impact quality of life. As a member of TheDrugClub, understanding your medication and how to manage its cost is a priority.

What Does Danazol Treat?

Danazol is primarily used to treat a few distinct conditions:

• Endometriosis: This is its most common use. It helps reduce the growth of endometrial tissue outside the uterus, alleviating pain and other symptoms associated with the condition.
• Fibrocystic Breast Disease: For severe cases characterized by pain and tenderness that don't respond to other treatments, danazol can help reduce nodularity and discomfort.
• Hereditary Angioedema: This rare genetic disorder causes recurrent episodes of swelling. Danazol is used to prevent these attacks by increasing levels of a specific blood protein.

It's important to note that danazol is typically reserved for more severe or refractory cases of these conditions due to its potential side effects and hormonal impact.

How Does Danazol Work?

Danazol works by suppressing the production of certain hormones, primarily those from the pituitary gland that stimulate the ovaries. This leads to a decrease in estrogen and progesterone levels. In the context of:

• Endometriosis: By reducing estrogen, it inhibits the growth and activity of endometrial tissue, causing it to shrink.
• Fibrocystic Breast Disease: Its hormonal effects can reduce breast pain and the size of cysts.
• Hereditary Angioedema: It increases the production of C1 esterase inhibitor, a protein that is deficient in individuals with this condition, thereby preventing swelling attacks.

Its action is complex, involving various endocrine pathways, making it a powerful tool for specific therapeutic needs.

Typical Costs of Danazol

While danazol is available as a generic medication, its cost can still be a significant

The information above is for educational purposes only and does not constitute medical advice. Consult your healthcare provider before making medication decisions.

What Danazol is approved for (FDA label)

Endometriosis. Danazol capsules are indicated for the treatment of endometriosis amenable to hormonal management. Hereditary Angioedema. Danazol capsules are indicated for the prevention of attacks of angioedema of all types (cutaneous, abdominal, laryngeal) in males and females.

Source: Read the full FDA label on DailyMed. Label effective date: October 10, 2024.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Boxed warning for Danazol (FDA label)

WARNINGS Use of danazol in pregnancy is contraindicated. A sensitive test (e.g., beta subunit test if available) capable of determining early pregnancy is recommended immediately prior to start of therapy. Additionally a non-hormonal method of contraception should be used during therapy. If a patient becomes pregnant while taking danazol, administration of the drug should be discontinued and the patient should be apprised of the potential risk to the fetus. Exposure to danazol in utero may result in androgenic effects on the female fetus; reports of clitoral hypertrophy, labial fusion, urogenital sinus defect, vaginal atresia, and ambiguous genitalia have been received (see PRECAUTIONS: Pregnancy, Teratogenic Effects ). Thromboembolism, thrombotic and thrombophlebitic events including sagittal sinus thrombosis and life-threatening or fatal strokes have been reported. Experience with long-term therapy with danazol is limited. Peliosis hepatis and benign hepatic adenoma have been observed with long-term use. Peliosis hepatis and hepatic adenoma may be silent until complicated by acute, potentially life-threatening intraabdominal hemorrhage. The physician therefore should be alert to this possibility. Attempts should be made to determine the lowest dose that will provide adequate protection. If the drug was begun at a time of exacerbation of hereditary angioneurotic edema due to trauma, stress or other cause, periodic attempts to decrease or withdraw therapy should be considered. Danazol has been associated with several cases of benign intracranial hypertension also known as pseudotumor cerebri.

Source: FDA prescribing information (DailyMed). Set ID: 55ad6325-16f6-4f0c-a1dc-734847052d0b. SPL document ID: 241f23e1-4b4b-4adb-e063-6394a90adcc5. Label effective date: October 10, 2024. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Adverse reactions for Danazol (FDA label)

The following events have been reported in association with the use of danazol capsules: Androgen like effects include weight gain, acne and seborrhea. Mild hirsutism, edema, hair loss, voice change, which may take the form of hoarseness, sore throat or of instability or deepening of pitch, may occur and may persist after cessation of therapy. Hypertrophy of the clitoris is rare. Other possible endocrine effects are menstrual disturbances including spotting, alteration of the timing of the cycle and amenorrhea. Although cyclical bleeding and ovulation usually return within 60-90 days after discontinuation of therapy with danazol capsules, persistent amenorrhea has occasionally been reported. Flushing, sweating, vaginal dryness and irritation and reduction in breast size, may reflect lowering of estrogen.

Source: FDA prescribing information (DailyMed). Set ID: 55ad6325-16f6-4f0c-a1dc-734847052d0b. SPL document ID: 241f23e1-4b4b-4adb-e063-6394a90adcc5. Label effective date: October 10, 2024. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Contraindications for Danazol (FDA label)

Danazol capsules should not be administered to patients with: Undiagnosed abnormal genital bleeding. Markedly impaired hepatic, renal, or cardiac function. Pregnancy (see WARNINGS ). Breast feeding. Porphyria-Danazol capsules can induce ALA synthetase activity and hence porphyrin metabolism. Androgen-dependent tumor. Active thrombosis or thromboembolic disease and history of such events. Hypersensitivity to danazol.

Source: FDA prescribing information (DailyMed). Set ID: 55ad6325-16f6-4f0c-a1dc-734847052d0b. SPL document ID: 241f23e1-4b4b-4adb-e063-6394a90adcc5. Label effective date: October 10, 2024. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.