Memantine — $0 on Listed Strengths

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About Memantine

Memantine is a crucial medication often prescribed to help manage moderate to severe Alzheimer's disease, working to improve memory, awareness, and the ability to perform daily tasks. Navigating the complexities of chronic conditions can be challenging, but accessing your prescriptions shouldn't be. With TheDrugClub, managing your health, including medications like memantine, becomes more affordable and convenient. For individuals and families facing the challenges of Alzheimer's disease, finding effective treatments and managing medication costs are top priorities. Memantine is a widely recognized medication that plays a significant role in managing the symptoms of moderate to severe Alzheimer's. ### What Memantine Treats

Memantine is primarily prescribed to treat moderate to severe Alzheimer's disease. While it's not a cure, it helps to improve cognitive function, including memory, thinking, reasoning, and the ability to perform daily activities. By managing these symptoms, memantine can help maintain a person's independence and quality of life for a longer period. It's often used in conjunction with other Alzheimer's medications or as a standalone treatment, depending on the individual's needs and the stage of their condition. ### How It Works

Memantine belongs to a class of drugs called NMDA receptor antagonists. In simple terms, it works by regulating the activity of a brain chemical called glutamate. Glutamate is an important neurotransmitter involved in learning and memory. However, in Alzheimer's disease, brain cells can be overstimulated by excessive amounts of glutamate, leading to neuronal damage and impaired cognitive function. Memantine helps to block this excessive glutamate activity, thereby protecting brain cells from damage and improving communication between neurons. This leads to a measurable improvement in cognitive symptoms and overall daily functioning for many patients. ### Typical Costs of Memantine

While a generic version of memantine hydrochloride (HCl) is available, making it generally more affordable than its brand-name counterpart, Namenda, the cost can still be a significant burden for many families. Without insurance, a monthly supply of generic memantine can range anywhere from $30 to over $100, depending on the dosage, the pharmacy you choose, and your geographical location. These costs can quickly add up, especially when combined with other medications and healthcare expenses associated with managing Alzheimer's disease. That's why we've made it incredibly

The information above is for educational purposes only and does not constitute medical advice. Consult your healthcare provider before making medication decisions.

What Memantine is approved for (FDA label)

Memantine hydrochloride tablets are indicated for the treatment of moderate to severe dementia of the Alzheimer’s type. Memantine hydrochloride tablets are an N-methyl-D-aspartate (NMDA) receptor antagonist indicated for the treatment of moderate to severe dementia of the Alzheimer’s type. ( 1 )

Source: Read the full FDA label on DailyMed. Label effective date: December 20, 2025.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Dosage forms and strengths for Memantine (FDA label)

Memantine Hydrochloride Tablet USP, 5 mg: orange colored, oblong, biconvex, film-coated tablets debossed “IP 173” on one side and plain on the other side. Memantine Hydrochloride Tablet USP, 10 mg: gray colored, oblong, biconvex, film-coated tablets debossed “IP 174” on one side and plain on the other side. Tablets: 5 mg and 10 mg ( 3 )

Source: FDA prescribing information (DailyMed). Set ID: f73e0df0-4af4-42f1-bde6-3cccb47ca378. SPL document ID: e3662d8d-b6da-40c6-84d4-1b5d467b1eb8. Label effective date: December 20, 2025. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Adverse reactions for Memantine (FDA label)

Most common adverse reactions (≥ 5 % and greater than placebo) are dizziness, headache, confusion and constipation. ( 6.1 ) To report SUSPECTED ADVERSE REACTIONS, contact Amneal Pharmaceuticals at 1-877-835-5472 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. 6.1 Clinical Trials Experience Memantine hydrochloride was evaluated in eight double-blind placebo-controlled trials involving a total of 1,862 dementia (Alzheimer’s disease, vascular dementia) patients (940 patients treated with memantine hydrochloride and 922 patients treated with placebo) for a treatment period up to 28 weeks.

Source: FDA prescribing information (DailyMed). Set ID: f73e0df0-4af4-42f1-bde6-3cccb47ca378. SPL document ID: e3662d8d-b6da-40c6-84d4-1b5d467b1eb8. Label effective date: December 20, 2025. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Contraindications for Memantine (FDA label)

Memantine hydrochloride tablets are contraindicated in patients with known hypersensitivity to memantine hydrochloride or to any excipients used in the formulation. Memantine hydrochloride tablets are contraindicated in patients with known hypersensitivity to memantine hydrochloride or to any excipients used in the formulation. ( 4 )

Source: FDA prescribing information (DailyMed). Set ID: f73e0df0-4af4-42f1-bde6-3cccb47ca378. SPL document ID: e3662d8d-b6da-40c6-84d4-1b5d467b1eb8. Label effective date: December 20, 2025. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Warnings and precautions for Memantine (FDA label)

Conditions that raise urine pH may decrease the urinary elimination of memantine, resulting in increased plasma levels of memantine. ( 5.1 , 7.1 ) 5.1 Genitourinary Conditions Conditions that raise urine pH may decrease the urinary elimination of memantine resulting in increased plasma levels of memantine [see Drug Interactions (7.1) ] .

Source: FDA prescribing information (DailyMed). Set ID: f73e0df0-4af4-42f1-bde6-3cccb47ca378. SPL document ID: e3662d8d-b6da-40c6-84d4-1b5d467b1eb8. Label effective date: December 20, 2025. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Drug interactions for Memantine (FDA label)

7.1 Drugs that Make the Urine Alkaline The clearance of memantine was reduced by about 80% under alkaline urine conditions at pH 8. Therefore, alterations of urine pH towards the alkaline condition may lead to an accumulation of the drug with a possible increase in adverse effects. Urine pH is altered by diet, drugs (e.g., carbonic anhydrase inhibitors, sodium bicarbonate) and clinical state of the patient (e.g., renal tubular acidosis or severe infections of the urinary tract). Hence, memantine should be used with caution under these conditions. 7.2 Use with Other N-methyl-D-aspartate (NMDA) Antagonists The combined use of memantine hydrochloride with other NMDA antagonists (amantadine, ketamine and dextromethorphan) has not been systematically evaluated and such use should be approached with caution.

Source: FDA prescribing information (DailyMed). Set ID: f73e0df0-4af4-42f1-bde6-3cccb47ca378. SPL document ID: e3662d8d-b6da-40c6-84d4-1b5d467b1eb8. Label effective date: December 20, 2025. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.