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Metolazone — $0 on Listed Strengths

Metolazone is $0 on listed strengths only. Other strengths are not a blanket $0.

Metolazone Pricing

Pricing typePrice
TheDrugClub$0 on listed strengths
Typical Retail$144.00

$0 on listed strengths: 2.5mg Tablet (max 90); 5mg Tablet (max 90)

About Metolazone

Metolazone is a prescription medication. Ask your doctor if Metolazone is right for you.

How to Check Metolazone Pricing

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Metolazone at Participating Pharmacies

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Other medications in Heart & Cardiovascular

About Metolazone

Metolazone is a potent diuretic often prescribed to manage conditions like high blood pressure and fluid retention. At TheDrugClub, we believe that essential medication should be accessible and affordable.

The information above is for educational purposes only and does not constitute medical advice. Consult your healthcare provider before making medication decisions.

What Metolazone is approved for (FDA label)

Metolazone tablets are indicated for the treatment of salt and water retention including: edema accompanying congestive heart failure; edema accompanying renal diseases, including the nephrotic syndrome and states of diminished renal function. Metolazone tablets are also indicated for the treatment of hypertension, alone or in combination with other antihypertensive drugs of a different class. Mykrox ® tablets, a more rapidly available form of metolazone, are intended for the treatment of new patients with mild to moderate hypertension. A dose titration is necessary if Mykrox ® tablets are to be substituted for Zaroxolyn ® tablets and other formulations of metolazone that share its slow and incomplete bioavailability, in the treatment of hypertension.

Source: Read the full FDA label on DailyMed. Label effective date: August 12, 2026.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Adverse reactions for Metolazone (FDA label)

Metolazone is usually well tolerated, and most reported adverse reactions have been mild and transient. Many metolazone related adverse reactions represent extensions of its expected pharmacologic activity and can be attributed to either its antihypertensive action or its renal/metabolic actions. The following adverse reactions have been reported. Several are single or comparably rare occurrences. Adverse reactions are listed in decreasing order of severity within body systems. Cardiovascular: Chest pain/discomfort, orthostatic hypotension, excessive volume depletion, hemoconcentration, venous thrombosis, palpitations. Central and Peripheral Nervous System: Syncope, neuropathy, vertigo, paresthesias, psychotic depression, impotence, dizziness/lightheadedness, drowsiness, fatigue, weakness, restlessness (sometimes resulting in insomnia), headache.

Source: FDA prescribing information (DailyMed). Set ID: efa8795e-2c89-4519-b49f-13146fb9ded1. SPL document ID: 58dae07d-ba01-99ad-e063-6394a90a2b62. Label effective date: August 12, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Contraindications for Metolazone (FDA label)

Anuria, hepatic coma or precoma, known allergy or hypersensitivity to metolazone.

Source: FDA prescribing information (DailyMed). Set ID: efa8795e-2c89-4519-b49f-13146fb9ded1. SPL document ID: 58dae07d-ba01-99ad-e063-6394a90a2b62. Label effective date: August 12, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Drug interactions for Metolazone (FDA label)

Diuretics Furosemide and probably other loop diuretics given concomitantly with metolazone can cause unusually large or prolonged losses of fluid and electrolytes (see WARNINGS ). Other Antihypertensives When metolazone tablets are used with other antihypertensive drugs, care must be taken, especially during initial therapy. Dosage adjustments of other antihypertensives may be necessary. Alcohol, Barbiturates, and Narcotics The hypotensive effects of these drugs may be potentiated by the volume contraction that may be associated with metolazone therapy. Digitalis Glycosides Diuretic-induced hypokalemia can increase the sensitivity of the myocardium to digitalis. Serious arrhythmias can result. Corticosteroids or ACTH May increase the risk of hypokalemia and increase salt and water retention. Lithium Serum lithium levels may increase (see WARNINGS ). Curariform Drugs Diuretic-induced hypokalemia may enhance neuromuscular blocking effects of curariform drugs (such as tubocurarine) - the most serious effect would be respiratory depression which could proceed to apnea.

Source: FDA prescribing information (DailyMed). Set ID: efa8795e-2c89-4519-b49f-13146fb9ded1. SPL document ID: 58dae07d-ba01-99ad-e063-6394a90a2b62. Label effective date: August 12, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

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