Nitrofurantoin monohydrate/macrocrystals — $0 with Membership

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Also listed for Urinary Tract Infection (Uncomplicated)

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About Nitrofurantoin monohydrate/macrocrystals

Nitrofurantoin monohydrate macrocrystals is a well-established antibiotic commonly prescribed to combat urinary tract infections (UTIs). Understanding your medication and how to access it affordably is key to good health. TheDrugClub is dedicated to making essential prescriptions like nitrofurantoin more accessible and budget-friendly for our members, often with significant savings and unparalleled convenience.

What Nitrofurantoin Monohydrate Macrocrystals Treats

Nitrofurantoin monohydrate macrocrystals is a powerful antibacterial medication primarily used to treat and prevent uncomplicated urinary tract infections (UTIs) caused by susceptible bacteria. Specifically, it's highly effective against bladder infections (cystitis). Its unique formulation as 'macrocrystals' allows for slower dissolution and absorption, which helps reduce gastrointestinal side effects and maintains effective drug concentrations in the urinary tract for longer periods.

How It Works

As an antibiotic, nitrofurantoin works by interfering with several bacterial enzyme systems, which are vital for the bacteria's metabolism and cell wall formation. This action prevents bacteria from growing and multiplying, ultimately leading to their death. What makes nitrofurantoin particularly effective for UTIs is its high concentration in the urine, while remaining relatively low in the blood. This targeted approach means it directly combats the infection where it resides – in the urinary tract – with minimal systemic exposure, making it a preferred choice for many UTI cases.

Typical Costs

While nitrofurantoin monohydrate macrocrystals is a generic medication, meaning it's generally more affordable than its brand-name counterparts, the cost can still vary significantly. Without insurance, a typical prescription might range anywhere from $15 to $50 or more, depending on the pharmacy, dosage, and quantity prescribed

The information above is for educational purposes only and does not constitute medical advice. Consult your healthcare provider before making medication decisions.

What Nitrofurantoin monohydrate/macrocrystals is approved for (FDA label)

Nitrofurantoin capsules, USP (monohydrate/macrocrystals) are indicated only for the treatment of acute uncomplicated urinary tract infections (acute cystitis) caused by susceptible strains of Escherichia coli or Staphylococcus saprophyticus . Nitrofurantoin is not indicated for the treatment of pyelonephritis or perinephric abscesses. To reduce the development of drug-resistant bacteria and maintain the effectiveness of nitrofurantoin capsules, USP (monohydrate/macrocrystals) and other antibacterial drugs, nitrofurantoin capsules, USP (monohydrate/macrocrystals) should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy.

Source: Read the full FDA label on DailyMed. Label effective date: October 30, 2024.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Adverse reactions for Nitrofurantoin monohydrate/macrocrystals (FDA label)

In clinical trials of nitrofurantoin, the most frequent clinical adverse events that were reported as possibly or probably drug-related were nausea (8%), headache (6%) and flatulence (1.5%). Additional clinical adverse events reported as possibly or probably drug-related occurred in less than 1% of patients studied and are listed below within each body system in order of decreasing frequency: Gastrointestinal: Diarrhea, dyspepsia, abdominal pain, constipation, emesis Neurologic: Dizziness, drowsiness, amblyopia Respiratory: Acute pulmonary hypersensitivity reaction (see WARNINGS ) Allergic: Pruritus, urticaria Dermatologic: Alopecia Miscellaneous: Fever, chills, malaise The following additional clinical adverse events have been reported with the use of nitrofurantoin: Gastrointestinal: Sialadenitis, pancreatitis. There have been sporadic reports of pseudomembranous colitis with the use of nitrofurantoin.

Source: FDA prescribing information (DailyMed). Set ID: 55c75f27-b5fc-4f19-8607-08f8ec0c69ec. SPL document ID: 7a5a2365-bab1-46d8-a6e6-95c623dbea9a. Label effective date: October 30, 2024. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Contraindications for Nitrofurantoin monohydrate/macrocrystals (FDA label)

Anuria, oliguria, or significant impairment of renal function (creatinine clearance under 60 mL per minute or clinically significant elevated serum creatinine) are contraindications. Treatment of this type of patient carries an increased risk of toxicity because of impaired excretion of the drug. Because of the possibility of hemolytic anemia due to immature erythrocyte enzyme systems (glutathione instability), the drug is contraindicated in pregnant patients at term (38 to 42 weeks gestation), during labor and delivery, or when the onset of labor is imminent. For the same reason, the drug is contraindicated in neonates under one month of age. Nitrofurantoin capsules (monohydrate/macrocrystals) are contraindicated in patients with a previous history of cholestatic jaundice/hepatic dysfunction associated with nitrofurantoin. Nitrofurantoin capsules (monohydrate/macrocrystals) are also contraindicated in those patients with known hypersensitivity to nitrofurantoin.

Source: FDA prescribing information (DailyMed). Set ID: 55c75f27-b5fc-4f19-8607-08f8ec0c69ec. SPL document ID: 7a5a2365-bab1-46d8-a6e6-95c623dbea9a. Label effective date: October 30, 2024. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Drug interactions for Nitrofurantoin monohydrate/macrocrystals (FDA label)

Antacids containing magnesium trisilicate, when administered concomitantly with nitrofurantoin, reduce both the rate and extent of absorption. The mechanism for this interaction probably is adsorption of nitrofurantoin onto the surface of magnesium trisilicate. Uricosuric drugs, such as probenecid and sulfinpyrazone, can inhibit renal tubular secretion of nitrofurantoin. The resulting increase in nitrofurantoin serum levels may increase toxicity, and the decreased urinary levels could lessen its efficacy as a urinary tract antibacterial. Drug/Laboratory Test Interactions As a result of the presence of nitrofurantoin, a false-positive reaction for glucose in the urine may occur. This has been observed with Benedict's and Fehling's solutions but not with the glucose enzymatic test.

Source: FDA prescribing information (DailyMed). Set ID: 55c75f27-b5fc-4f19-8607-08f8ec0c69ec. SPL document ID: 7a5a2365-bab1-46d8-a6e6-95c623dbea9a. Label effective date: October 30, 2024. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.