Pimozide — Membership Pricing

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About Pimozide

Pimozide is a medication primarily used to manage severe tics associated with Tourette's Syndrome. As an antipsychotic, it plays a crucial role for those unresponsive to other treatments. Understanding its purpose and how to afford it is essential. With TheDrugClub, members can access significant savings on prescriptions like Pimozide, helping make vital treatments more accessible and manageable.

Pimozide is an antipsychotic medication primarily prescribed for the treatment of severe motor and vocal tics associated with Tourette's Syndrome. It is typically considered when other, less potent treatments have proven ineffective. Tourette's Syndrome is a neurological disorder characterized by involuntary, repetitive movements and vocalizations called tics. While Pimozide does not cure Tourette's Syndrome, it can significantly reduce the frequency and severity of these tics, improving the quality of life for individuals struggling with this condition.

How Pimozide Works

Pimozide belongs to a class of medications known as dopamine receptor blockers, specifically acting as a D2 dopamine receptor antagonist. In simpler terms, it works by blocking the effects of dopamine, a neurotransmitter in the brain that plays a role in movement, motivation, and reward. By reducing the activity of dopamine in certain areas of the brain, Pimozide helps to calm the overactive nerve signals that contribute to the involuntary tics seen in Tourette's Syndrome. This action helps to restore a more balanced chemical environment in the brain, leading to a reduction in tic symptoms.

Typical Costs of Pimozide

As a generic medication, Pimozide can still represent a significant out-

The information above is for educational purposes only and does not constitute medical advice. Consult your healthcare provider before making medication decisions.

What Pimozide is approved for (FDA label)

Pimozide tablets, USP are indicated for the suppression of motor and phonic tics in patients with Tourette’s Disorder who have failed to respond satisfactorily to standard treatment. Pimozide tablets, USP are not intended as a treatment of first choice nor is it intended for the treatment of tics that are merely annoying or cosmetically troublesome. Pimozide tablets, USP should be reserved for use in Tourette’s Disorder patients whose development and/or daily life function is severely compromised by the presence of motor and phonic tics. Evidence supporting approval of pimozide tablets, USP for use in Tourette’s Disorder was obtained in two controlled clinical investigations which enrolled patients between the ages of 8 and 53 years.

Source: Read the full FDA label on DailyMed. Label effective date: August 12, 2026.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Adverse reactions for Pimozide (FDA label)

General Extrapyramidal Reactions: Neuromuscular (extrapyramidal) reactions during the administration of pimozide have been reported frequently, often during the first few days of treatment. In most patients, these reactions involved Parkinson-like symptoms which, when first observed, were usually mild to moderately severe and usually reversible. Other types of neuromuscular reactions (motor restlessness, dystonia, akathisia, hyperreflexia, opisthotonos, oculogyric crises) have been reported far less frequently. Severe extrapyramidal reactions have been reported to occur at relatively low doses. Generally the occurrence and severity of most extrapyramidal symptoms are dose-related since they occur at relatively high doses and have been shown to disappear or become less severe when the dose is reduced.

Source: FDA prescribing information (DailyMed). Set ID: 70b079e2-a1f7-4a93-8685-d60a4d7c1280. SPL document ID: a3c5958c-a773-4d10-ae80-9cd453bf07fe. Label effective date: August 12, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Contraindications for Pimozide (FDA label)

1. Pimozide is contraindicated in the treatment of simple tics or tics other than those associated with Tourette’s Disorder. 2. Pimozide should not be used in patients taking drugs that may, themselves, cause motor and phonic tics (e.g., pemoline, methylphenidate and amphetamines) until such patients have been withdrawn from these drugs to determine whether or not the drugs, rather than Tourette’s Disorder, are responsible for the tics. 3. Because pimozide prolongs the QT interval of the electrocardiogram it is contraindicated in patients with congenital long QT syndrome, patients with a history of cardiac arrhythmias, patients taking other drugs which prolong the QT interval of the electrocardiogram or patients with known hypokalemia or hypomagnesemia (see also PRECAUTIONS - DRUG INTERACTIONS ). 4. Pimozide is contraindicated in patients with severe toxic central nervous system depression or comatose states from any cause. 5. Pimozide is contraindicated in patients with hypersensitivity to it.

Source: FDA prescribing information (DailyMed). Set ID: 70b079e2-a1f7-4a93-8685-d60a4d7c1280. SPL document ID: a3c5958c-a773-4d10-ae80-9cd453bf07fe. Label effective date: August 12, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Drug interactions for Pimozide (FDA label)

Because pimozide prolongs the QT interval of the electrocardiogram, an additive effect on QT interval would be anticipated if administered with other drugs, such as phenothiazines, tricyclic antidepressants or antiarrhythmic agents, which prolong the QT interval. Accordingly, pimozide should not be given with dofetilide, sotalol, quinidine, other Class Ia and III anti-arrhythmics, mesoridazine, thioridazine, chlorpromazine, droperidol, sparfloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, pentamidine, arsenic trioxide, levomethadyl acetate, dolasetron mesylate, probucol, tacrolimus, ziprasidone, or other drugs that have demonstrated QT prolongation as one of their pharmacodynamic effects. Also, the use of macrolide antibiotics in patients with prolonged QT intervals has been rarely associated with ventricular arrhythmias. Such concomitant administration should not be undertaken (see CONTRAINDICATIONS ). Since pimozide is partly metabolized via CYP 3A4, it should not be administered concomitantly with inhibitors of this metabolic system, such as azole antifungal agents and protease inhibitor drugs (see CONTRAINDICATIONS ).

Source: FDA prescribing information (DailyMed). Set ID: 70b079e2-a1f7-4a93-8685-d60a4d7c1280. SPL document ID: a3c5958c-a773-4d10-ae80-9cd453bf07fe. Label effective date: August 12, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.