Propylthiouracil — $0 with Membership

Related medications

Other medications associated with the same conditions in this catalog.

Also listed for Hyperthyroidism

• Atenolol
• Methimazole
• Propranolol

Other medications in Endocrine

• Cholecalciferol
• Ergocalciferol
• Levothyroxine
• Liothyronine

About Propylthiouracil

Propylthiouracil, commonly known as PTU, is a crucial medication for individuals managing an overactive thyroid. This powerful drug helps restore balance to your body, alleviating uncomfortable symptoms associated with hyperthyroidism. At TheDrugClub, we believe essential medications like PTU should be accessible and affordable. Discover how our membership can help you save significantly, potentially even getting your prescription for $0 with free home delivery.

The information above is for educational purposes only and does not constitute medical advice. Consult your healthcare provider before making medication decisions.

What Propylthiouracil is approved for (FDA label)

Propylthiouracil is indicated: in patients with Graves’ disease with hyperthyroidism or toxic multinodular goiter who are intolerant of methimazole and for whom surgery or radioactive iodine therapy is not an appropriate treatment option to ameliorate symptoms of hyperthyroidism in preparation for thyroidectomy or radioactive iodine therapy in patients who are intolerant of methimazole

Source: Read the full FDA label on DailyMed. Label effective date: August 27, 2026.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Boxed warning for Propylthiouracil (FDA label)

WARNING Severe liver injury and acute liver failure, in some cases fatal, have been reported in patients treated with propylthiouracil. These reports of hepatic reactions include cases requiring liver transplantation in adult and pediatric patients. Propylthiouracil should be reserved for patients who cannot tolerate methimazole and in whom radioactive iodine therapy or surgery are not appropriate treatments for the management of hyperthyroidism. Propylthiouracil may be the treatment of choice when an antithyroid drug is indicated during or just prior to the first trimester of pregnancy (see Warnings and Precautions ).

Source: FDA prescribing information (DailyMed). Set ID: d819e532-09ac-434a-84a6-636c4204c7aa. SPL document ID: 5a08b89c-d38c-ccd7-e063-6394a90aaba1. Label effective date: August 27, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Adverse reactions for Propylthiouracil (FDA label)

The following adverse reactions have been reported with the use of propylthiouracil. Because these events generally come from voluntary reporting from a population of uncertain size, it is not possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Severe adverse reactions include liver injury presenting as hepatitis, liver failure necessitating liver transplantation or resulting in death (see WARNINGS ). Inhibition of myelopoiesis (agranulocytosis, granulopenia, aplastic anemia, and thrombocytopenia), drug fever, a lupus-like syndrome (including splenomegaly and vasculitis), periarteritis, hypoprothrombinemia, and bleeding have been reported. Nephritis, glomerulonephritis, interstitial pneumonitis, exfoliative dermatitis, and erythema nodosum have also been reported.

Source: FDA prescribing information (DailyMed). Set ID: d819e532-09ac-434a-84a6-636c4204c7aa. SPL document ID: 5a08b89c-d38c-ccd7-e063-6394a90aaba1. Label effective date: August 27, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Contraindications for Propylthiouracil (FDA label)

Propylthiouracil is contraindicated in patients who have demonstrated hypersensitivity to the drug or any of the other product components.

Source: FDA prescribing information (DailyMed). Set ID: d819e532-09ac-434a-84a6-636c4204c7aa. SPL document ID: 5a08b89c-d38c-ccd7-e063-6394a90aaba1. Label effective date: August 27, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Drug interactions for Propylthiouracil (FDA label)

Anticoagulants (oral): Due to the potential inhibition of vitamin K activity by propylthiouracil, the activity of oral anticoagulants (e.g., warfarin) may be increased; additional monitoring of PT/INR should be considered, especially before surgical procedures. Beta-adrenergic blocking agents: Hyperthyroidism may cause an increased clearance of beta blockers with a high extraction ratio. A reduced dose of beta-adrenergic blockers may be needed when a hyperthyroid patient becomes euthyroid. Digitalis glycosides: Serum digitalis levels may be increased when hyperthyroid patients on a stable digitalis glycoside regimen become euthyroid; a reduced dose of digitalis glycosides may be needed. Theophylline: Theophylline clearance may decrease when hyperthyroid patients on a stable theophylline regimen become euthyroid; a reduced dose of theophylline may be needed.

Source: FDA prescribing information (DailyMed). Set ID: d819e532-09ac-434a-84a6-636c4204c7aa. SPL document ID: 5a08b89c-d38c-ccd7-e063-6394a90aaba1. Label effective date: August 27, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.