Pyrazinamide — Discount Pricing

Other medications in Infections

• Raltegravir
• Rifampin
• Rilpivirine
• Sofosbuvir
• Tedizolid
• Tenofovir
• Terbinafine
• Tetracycline

About Pyrazinamide

Pyrazinamide is a vital medication used in the comprehensive treatment of tuberculosis (TB). Its role is crucial in combating this serious infection, but managing prescription costs can be a concern. TheDrugClub is committed to making essential medications like pyrazinamide more accessible and affordable for our members, offering various ways to save on your prescription.

What is Pyrazinamide and What Does It Treat?

Pyrazinamide is an important antibiotic primarily used in the treatment of tuberculosis (TB), a serious bacterial infection that usually affects the lungs but can also impact other parts of the body. It is almost always prescribed as part of a multi-drug regimen, never alone, to prevent the development of drug resistance and ensure effective eradication of the *Mycobacterium tuberculosis* bacteria. Its inclusion in a combination therapy is key to the short-course treatment of TB.

How Does Pyrazinamide Work?

Pyrazinamide is considered a pro-drug, meaning it's inactive until it's metabolized in the body. Once inside the *Mycobacterium tuberculosis* cells, an enzyme called pyrazinamidase converts it into its active form: pyrazinoic acid. This active compound then disrupts several vital processes within the bacterial cell, including membrane function, energy metabolism, and protein synthesis. Pyrazinoic acid is particularly effective in the acidic environment often found within the macrophages where TB bacteria reside, making it a powerful component of the treatment strategy. Its unique mechanism helps to kill persistent bacteria that other TB drugs might miss.

Typical Costs of Pyrazinamide

The cost of pyrazinamide can vary significantly based on several factors, including the dosage prescribed, the duration of treatment, the specific pharmacy you use, and your insurance coverage status. Without insurance or a prescription savings program, the out-of-pocket cost for a course of pyrazinamide can be substantial, potentially ranging from tens to hundreds of dollars for a typical supply. These costs can accumulate over the months-long treatment period required for TB, making affordability a critical concern for many patients.

How TheDrugClub Helps You Save

At TheDrugClub, we understand the financial burden that prescription medications can impose. For members needing pyrazinamide, there are several ways we help reduce costs. If your health insurance plan, accessible through your TheDrugClub membership, includes pyrazin

The information above is for educational purposes only and does not constitute medical advice. Consult your healthcare provider before making medication decisions.

What Pyrazinamide is approved for (FDA label)

Pyrazinamide is indicated for the initial treatment of active tuberculosis in adults and children when combined with other antituberculous agents. (The current recommendation of the CDC for drug-susceptible disease is to use a six-month regimen for initial treatment of active tuberculosis, consisting of isoniazid, rifampin and pyrazinamide given for 2 months, followed by isoniazid and rifampin for 4 months. *4 ) (Patients with drug-resistant disease should be treated with regimens individualized to their situation.

Source: Read the full FDA label on DailyMed. Label effective date: March 2, 2026.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Adverse reactions for Pyrazinamide (FDA label)

General Fever, porphyria and dysuria have rarely been reported. Gout (see PRECAUTIONS ). Gastrointestinal The principal adverse effect is a hepatic reaction (see WARNINGS ). Hepatotoxicity appears to be dose related, and may appear at any time during therapy. GI disturbances including nausea, vomiting and anorexia have also been reported. Hematologic and Lymphatic Thrombocytopenia and sideroblastic anemia with erythroid hyperplasia, vacuolation of erythrocytes and increased serum iron concentration have occurred rarely with this drug. Adverse effects on blood clotting mechanisms have also been rarely reported. Other Mild arthralgia and myalgia have been reported frequently. Hypersensitivity reactions including rashes, urticaria, and pruritus have been reported. Fever, acne, photosensitivity, porphyria, dysuria and interstitial nephritis have been reported rarely.

Source: FDA prescribing information (DailyMed). Set ID: 262d8829-728c-48db-b89b-88d13b87e684. SPL document ID: e043f21d-4a30-4d23-bc03-12207af7d6d7. Label effective date: March 2, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.