Sildenafil 25/50/100 mg tabs — $0 with Membership

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Also listed for Erectile Dysfunction

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About Sildenafil 25/50/100 mg tabs

Sildenafil, available in 25 mg, 50 mg, and 100 mg tablets, is a widely prescribed medication primarily known for treating erectile dysfunction. It has helped countless individuals improve their quality of life. At TheDrugClub, we believe essential medications should be affordable and accessible. Discover how our membership can significantly reduce your costs for sildenafil, often to a $0 co-pay with free home delivery.

What Sildenafil Treats

Sildenafil is a versatile medication primarily known for its effectiveness in treating Erectile Dysfunction (ED). ED is a common condition where a man has difficulty achieving or maintaining an erection firm enough for sexual intercourse. Sildenafil works to improve blood flow to the penis, making it easier to get and sustain an erection when sexually aroused.

Beyond ED, sildenafil is also prescribed under a different brand name (Revatio) for Pulmonary Arterial Hypertension (PAH), a serious condition where blood pressure in the arteries leading to the lungs is abnormally high. While the focus of sildenafil 25, 50, and 100 mg tablets is typically ED, it's important to always take medication as prescribed by your healthcare provider.

How Sildenafil Works

Sildenafil belongs to a class of drugs called phosphodiesterase-5 (PDE5) inhibitors. When a man is sexually stimulated, nitric oxide is released in the penis, which activates an enzyme that produces cyclic guanosine monophosphate (cGMP). cGMP causes the smooth muscles in the penis to relax, allowing increased blood flow and an erection. PDE5 is an enzyme that breaks down cGMP, ending the erection. Sildenafil works by inhibiting PDE5, thereby increasing and prolonging the effects of cGMP. This means more blood flow to the penis, leading to a firmer and longer-lasting erection when sexual stimulation occurs. It's crucial to remember that sildenafil does not cause an erection on its own; sexual arousal is still necessary.

Typical Costs for Sildenafil

The cost of sildenafil can vary significantly

The information above is for educational purposes only and does not constitute medical advice. Consult your healthcare provider before making medication decisions.

What Sildenafil 25/50/100 mg tabs is approved for (FDA label)

Sildenafil tablets are indicated for the treatment of erectile dysfunction. Sildenafil tablet is a phosphodiesterase-5 (PDE5) inhibitor indicated for the treatment of erectile dysfunction (ED) (1)

Source: Read the full FDA label on DailyMed. Label effective date: August 31, 2026.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Dosage forms and strengths for Sildenafil 25/50/100 mg tabs (FDA label)

Sildenafil Tablets USP, 25 mg are white colored, round-shaped, biconvex, film coated tablets debossed with 'I' on one side and '35' on the other side. Sildenafil Tablets USP, 50 mg are white colored, round-shaped, biconvex, film coated tablets debossed with 'I' on one side and '36' on the other side. Sildenafil Tablets USP, 100 mg are white colored, round-shaped, biconvex, film coated tablets debossed with 'I' on one side and '58' on the other side. Tablets: 25 mg, 50 mg, 100 mg (3)

Source: FDA prescribing information (DailyMed). Set ID: 174ef537-e3e6-42bd-a478-47b930ddc761. SPL document ID: 28fbd804-8f01-4e84-aba8-76ad8614fb99. Label effective date: August 31, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Adverse reactions for Sildenafil 25/50/100 mg tabs (FDA label)

The following are discussed in more detail in other sections of the labeling: • Cardiovascular [see Warnings and Precautions (5.1)] • Prolonged Erection and Priapism [see Warnings and Precautions (5.2)] • Effects on the Eye [see Warnings and Precautions (5.3)] • Hearing Loss [ see Warnings and Precautions (5.4)] • Hypotension when Co-administered with Alpha-blockers or Anti-hypertensives [see Warnings and Precautions (5.5)] • Adverse Reactions with the Concomitant Use of Ritonavir [see Warnings and Precautions (5.6)] • Combination with other PDE5 Inhibitors or Other Erectile Dysfunction Therapies [see Warnings and Precautions (5.7)] • Effects on Bleeding [see Warnings and Precautions (5.8)] • Counseling Patients About Sexually Transmitted Diseases [see Warnings and Precautions (5.9)] The most common adverse reactions reported in clinical trials (≥ 2%) are headache, flushing, dyspepsia, abnormal vision, nasal congestion, back pain, myalgia, nausea, dizziness, and rash.

Source: FDA prescribing information (DailyMed). Set ID: 174ef537-e3e6-42bd-a478-47b930ddc761. SPL document ID: 28fbd804-8f01-4e84-aba8-76ad8614fb99. Label effective date: August 31, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Contraindications for Sildenafil 25/50/100 mg tabs (FDA label)

• Administration of sildenafil tablets to patients using nitric oxide donors, such as organic nitrates or organic nitrites in any form. Sildenafil tablets were shown to potentiate the hypotensive effect of nitrates ( 4.1 , 7.1 , 12.2 ) • Known hypersensitivity to sildenafil or any component of tablet (4.2) • Administration with guanylate cyclase (GC) stimulators, such as riociguat (4.3) 4.1 Nitrates Consistent with its known effects on the nitric oxide/cGMP pathway [ see Clinical Pharmacology ( 12.1 , 12.2)] , sildenafil tablets were shown to potentiate the hypotensive effects of nitrates, and its administration to patients who are using nitric oxide donors such as organic nitrates or organic nitrites in any form either regularly and/or intermittently is therefore contraindicated. After patients have taken sildenafil tablets, it is unknown when nitrates, if necessary, can be safely administered.

Source: FDA prescribing information (DailyMed). Set ID: 174ef537-e3e6-42bd-a478-47b930ddc761. SPL document ID: 28fbd804-8f01-4e84-aba8-76ad8614fb99. Label effective date: August 31, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Warnings and precautions for Sildenafil 25/50/100 mg tabs (FDA label)

• Patients should not use sildenafil tablets if sexual activity is inadvisable due to cardiovascular status (5.1) • Patients should seek emergency treatment if an erection lasts >4 hours. Use sildenafil tablets with caution in patients predisposed to priapism (5.2) • Patients should stop sildenafil tablets and seek medical care if a sudden loss of vision occurs in one or both eyes, which could be a sign of non arteritic anterior ischemic optic neuropathy (NAION). Sildenafil tablets should be used with caution, and only when the anticipated benefits outweigh the risks, in patients with a history of NAION. Patients with a ”crowded” optic disc may also be at an increased risk of NAION. (5.3) • Patients should stop sildenafil tablets and seek prompt medical attention in the event of sudden decrease or loss of hearing (5.4) • Caution is advised when sildenafil tablets are co-administered with alpha-blockers or anti-hypertensives.

Source: FDA prescribing information (DailyMed). Set ID: 174ef537-e3e6-42bd-a478-47b930ddc761. SPL document ID: 28fbd804-8f01-4e84-aba8-76ad8614fb99. Label effective date: August 31, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Drug interactions for Sildenafil 25/50/100 mg tabs (FDA label)

• Sildenafil tablets can potentiate the hypotensive effects of nitrates, alpha blockers, and anti-hypertensives ( 4.1 , 5.5 , 7.1 , 7.2 , 7.3 , 12.2 ) • With concomitant use of alpha blockers, initiate sildenafil tablets at 25 mg dose (2.3) • CYP3A4 inhibitors (e.g., ritonavir, ketoconazole, itraconazole, erythromycin): Increase sildenafil tablets exposure (2.4 , 7.4 , 12.3 ) • Ritonavir: Do not exceed a maximum single dose of 25 mg in a 48 hour period ( 2.4 , 5.6) • Erythromycin or strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, saquinavir): Consider a starting dose of 25 mg (2.4, 7.4) 7.1 Nitrates Administration of sildenafil tablets with nitric oxide donors such as organic nitrates or organic nitrites in any form is contraindicated.

Source: FDA prescribing information (DailyMed). Set ID: 174ef537-e3e6-42bd-a478-47b930ddc761. SPL document ID: 28fbd804-8f01-4e84-aba8-76ad8614fb99. Label effective date: August 31, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.