Trazodone — $0 on Listed Strengths

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About Trazodone

Trazodone is a widely prescribed medication primarily used to treat depression, and often, insomnia. If you or a loved one relies on this important medication, managing its cost can be a concern. TheDrugClub is dedicated to making essential prescriptions like trazodone accessible and affordable, ensuring you can get the care you need without financial strain.

What Does Trazodone Treat?

Trazodone is an antidepressant medication approved by the FDA primarily for the treatment of major depressive disorder. It helps improve mood, sleep, appetite, and energy levels in individuals suffering from depression. Beyond its primary indication, trazodone is also frequently prescribed off-label at lower doses to help manage insomnia, particularly in patients who experience difficulty falling or staying asleep. Its sedating effects make it a popular choice for those seeking relief from sleep disturbances, often when other sleep aids are not suitable or effective.

How Does Trazodone Work?

As a serotonin antagonist and reuptake inhibitor (SARI), trazodone works by affecting the balance of serotonin in the brain. Serotonin is a neurotransmitter that plays a key role in mood, sleep, and overall well-being. Trazodone increases the amount of serotonin available in the brain by blocking its reuptake, leading to improved mood. Additionally, it blocks certain serotonin receptors (like 5-HT2A), which contributes to its sedative properties, making it effective for sleep. Unlike some other antidepressants, trazodone has a relatively low risk of certain side effects often associated with other classes of antidepressants, such as sexual dysfunction.

Typical Costs of Trazodone

The retail price for trazodone can vary significantly depending on the dosage, quantity, and the pharmacy you use. Without insurance, a typical prescription for 30 tablets of 50mg generic trazodone can range anywhere from $15 to $50

The information above is for educational purposes only and does not constitute medical advice. Consult your healthcare provider before making medication decisions.

What Trazodone is approved for (FDA label)

Trazodone hydrochloride tablets are indicated for the treatment of major depressive disorder (MDD) in adults. Trazodone hydrochloride tablets are a selective serotonin reuptake inhibitor indicated for the treatment of major depressive disorder (MDD) ( 1 ).

Source: Read the full FDA label on DailyMed. Label effective date: September 8, 2026.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Boxed warning for Trazodone (FDA label)

WARNING: SUICIDAL THOUGHTS AND BEHAVIORS Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients in short-term studies. Closely monitor all antidepressant-treated patients for clinical worsening, and for emergence of suicidal thoughts and behaviors [see Warnings and Precautions (5.1) ]. Trazodone hydrochloride tablets are not approved for use in pediatric patients [see Use in Specific Populations (8.4) ]. WARNING: SUICIDAL THOUGHTS AND BEHAVIORS See full prescribing information for complete boxed warning. Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients ( 5.1 ) Closely monitor for clinical worsening and emergence of suicidal thoughts and behaviors ( 5.1 ) Trazodone hydrochloride tablets are not approved for use in pediatric patients ( 8.4 )

Source: FDA prescribing information (DailyMed). Set ID: fa7afa93-b98c-4dc7-bbb8-ab6a058427b9. SPL document ID: 5afe0778-c45c-6b25-e063-6394a90a7aa3. Label effective date: September 8, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Dosage forms and strengths for Trazodone (FDA label)

Trazodone hydrochloride tablets, USP are available in the following strengths: Trazodone hydrochloride tablets, USP 50 mg are white, round, convex, bisected, film-coated tablets, debossed ‘S/14’ on one side and having ‘break-line’ on other side Bisectable tablets of 50 mg ( 3 ).

Source: FDA prescribing information (DailyMed). Set ID: fa7afa93-b98c-4dc7-bbb8-ab6a058427b9. SPL document ID: 5afe0778-c45c-6b25-e063-6394a90a7aa3. Label effective date: September 8, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Adverse reactions for Trazodone (FDA label)

The following serious adverse reactions are described elsewhere in the labeling: Suicidal Thoughts and Behavior in Children, Adolescents and Young Adults [see Boxed Warning and Warnings and Precautions (5.1) ] Serotonin Syndrome [see Warnings and Precautions (5.2) ] Cardiac Arrhythmias [see Warnings and Precautions (5.3) ] Orthostatic Hypotension and Syncope [see Warnings and Precautions (5.4) ] Increased Risk of Bleeding [see Warnings and Precautions (5.5) ] Priapism [see Warnings and Precautions (5.6) ] Activation of Mania or Hypomania [see Warnings and Precautions (5.7) ] Discontinuation Syndrome [see Warnings and Precautions (5.8) ] Potential for Cognitive and Motor Impairment [see Warnings and Precautions (5.9) ] Angle-Closure Glaucoma [see Warnings and Precautions (5.10) ] Hyponatremia [see Warnings and Precautions (5.11) ] Most common adverse reactions (incidence ≥ 5% and twice that of placebo) are: edema, blurred vision, syncope, drowsiness, fatigue, diarrhea, nasal congestion, weight loss ( 6 ).

Source: FDA prescribing information (DailyMed). Set ID: fa7afa93-b98c-4dc7-bbb8-ab6a058427b9. SPL document ID: 5afe0778-c45c-6b25-e063-6394a90a7aa3. Label effective date: September 8, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Contraindications for Trazodone (FDA label)

Trazodone hydrochloride tablets are contraindicated in: Patients taking, or within 14 days of stopping, monoamine oxidase inhibitors (MAOIs), including MAOIs such as linezolid or intravenous methylene blue, because of an increased risk of serotonin syndrome [see Warnings and Precautions (5.2) , Drug Interactions (7.1) ]. Concomitant use of monoamine oxidase inhibitors (MAOIs), or use within 14 days of stopping MAOIs ( 4 ).

Source: FDA prescribing information (DailyMed). Set ID: fa7afa93-b98c-4dc7-bbb8-ab6a058427b9. SPL document ID: 5afe0778-c45c-6b25-e063-6394a90a7aa3. Label effective date: September 8, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Warnings and precautions for Trazodone (FDA label)

Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents (e.g., SSRI, SNRI, triptans), but also when taken alone. If it occurs, discontinue trazodone hydrochloride tablets and initiate supportive treatment ( 5.2 ). Cardiac Arrhythmias: Increases the QT interval. Avoid use with drugs that also increase the QT interval and in patients with risk factors for prolonged QT interval ( 5.3 ) Orthostatic Hypotension and Syncope: Warn patients of risk and symptoms of hypotension ( 5.4 ). Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.5 ). Priapism: Cases of painful and prolonged penile erections and priapism have been reported. Immediate medical attention should be sought if signs and symptoms of prolonged penile erections or priapism are observed ( 5.6 ).

Source: FDA prescribing information (DailyMed). Set ID: fa7afa93-b98c-4dc7-bbb8-ab6a058427b9. SPL document ID: 5afe0778-c45c-6b25-e063-6394a90a7aa3. Label effective date: September 8, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Drug interactions for Trazodone (FDA label)

CNS Depressants: Trazodone hydrochloride tablets may enhance effects of alcohol, barbiturates, or other CNS depressants ( 7 ). CYP3A4 Inhibitors: Consider trazodone hydrochloride tablets dose reduction based on tolerability ( 2.5 , 7 ). CYP3A4 Inducers: Increase in trazodone hydrochloride tablets dosage may be necessary ( 2.5 , 7 ). Digoxin or Phenytoin: Monitor for increased digoxin or phenytoin serum levels ( 7 ). Warfarin: Monitor for increased or decreased prothrombin time ( 7 ). 7.1 Drugs Having Clinically Important Interactions with Trazodone Hydrochloride Tablets Table 3: Clinically Important Drug Interactions with Trazodone Hydrochloride Tablets Monoamine Oxidase Inhibitors (MAOIs) Clinical Impact: The concomitant use of MAOIs and serotonergic drugs including trazodone hydrochloride tablets increases the risk of serotonin syndrome.

Source: FDA prescribing information (DailyMed). Set ID: fa7afa93-b98c-4dc7-bbb8-ab6a058427b9. SPL document ID: 5afe0778-c45c-6b25-e063-6394a90a7aa3. Label effective date: September 8, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.