Trimethoprim-Sulfamethoxazole — Membership Pricing
Trimethoprim-Sulfamethoxazole is not confirmed for no-additional-cost pricing. Membership pricing may be available; confirm the price with the dispensing pharmacy.
Trimethoprim-Sulfamethoxazole Pricing
| Pricing type | Price |
|---|---|
| TheDrugClub | Membership pricing may be available |
| Typical Retail | $91.00 |
Membership pricing may be available; confirm the price with the dispensing pharmacy.
About Trimethoprim-Sulfamethoxazole
Trimethoprim-Sulfamethoxazole is a prescription medication. Ask your doctor if Trimethoprim-Sulfamethoxazole is right for you.
How to Check Trimethoprim-Sulfamethoxazole Pricing
- Join TheDrugClub for $19.95/month
- Receive your member card by email
- Present your card at a participating pharmacy
- Check active-formulary eligibility or available membership pricing
Trimethoprim-Sulfamethoxazole at Participating Pharmacies
- CVS Pharmacy
- Walgreens
- Walmart Pharmacy
- Rite Aid
- Kroger Pharmacy
- Costco Pharmacy
- Albertsons
- Safeway
- Publix Pharmacy
- H-E-B Pharmacy
Pharmacy participation and fulfillment options vary. Present your membership card and confirm current pricing before filling.
Other medications in Infections
About Trimethoprim-Sulfamethoxazole
Trimethoprim sulfamethoxazole (TMP-SMX) is a combination antibiotic used to treat a wide range of bacterial infections. Whether you're dealing with a urinary tract infection or respiratory illness, this medication has been a trusted choice for decades.
The information above is for educational purposes only and does not constitute medical advice. Consult your healthcare provider before making medication decisions.
What Trimethoprim-Sulfamethoxazole is approved for (FDA label)
Urinary Tract Infections: For the treatment of urinary tract infections due to susceptible strains of the following organisms: Escherichia coli , Klebsiella species, Enterobacter species, Morganella morganii , Proteus mirabilis and Proteus vulgaris . It is recommended that initial episodes of uncomplicated urinary tract infections be treated with a single effective antibacterial agent rather than the combination. Acute Otitis Media: For the treatment of acute otitis media in pediatric patients due to susceptible strains of Streptococcus pneumoniae or Haemophilus influenzae when in the judgment of the physician sulfamethoxazole and trimethoprim offers some advantage over the use of other antimicrobial agents.
Source: Read the full FDA label on DailyMed. Label effective date: September 2, 2026.
Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.
Adverse reactions for Trimethoprim-Sulfamethoxazole (FDA label)
The following adverse reactions associated with the use of sulfamethoxazole and trimethoprim were identified in clinical trials, postmarketing or published reports. Because some of these reactions were reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. The most common adverse reactions are gastrointestinal disturbances (nausea, vomiting, anorexia) and allergic skin reactions (such as rash and urticaria).
Source: FDA prescribing information (DailyMed). Set ID: c6171b62-835c-465e-905e-97f70438186e. SPL document ID: fc2caf1b-56ae-49f5-be07-f9c706b6b77a. Label effective date: September 2, 2026. Read the full label.
Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.
Contraindications for Trimethoprim-Sulfamethoxazole (FDA label)
Sulfamethoxazole and trimethoprim is contraindicated in the following situations: • known hypersensitivity to trimethoprim or sulfonamides • history of drug-induced immune thrombocytopenia with use of trimethoprim and/or sulfonamides • documented megaloblastic anemia due to folate deficiency • pediatric patients less than 2 months of age • marked hepatic damage • severe renal insufficiency when renal function status cannot be monitored • concomitant administration with dofetilide (see PRECAUTIONS ).
Source: FDA prescribing information (DailyMed). Set ID: c6171b62-835c-465e-905e-97f70438186e. SPL document ID: fc2caf1b-56ae-49f5-be07-f9c706b6b77a. Label effective date: September 2, 2026. Read the full label.
Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.
Drug interactions for Trimethoprim-Sulfamethoxazole (FDA label)
Potential for Sulfamethoxazole and Trimethoprim to Affect Other Drugs Trimethoprim is an inhibitor of CYP2C8 as well as OCT2 transporter. Sulfamethoxazole is an inhibitor of CYP2C9. Avoid coadministration of sulfamethoxazole and trimethoprim with drugs that are substrates of CYP2C8 and 2C9 or OCT2. Table 1: Drug Interactions with Sulfamethoxazole and Trimethoprim Drug(s) Recommendation Comments Diuretics Avoid concurrent use In elderly patients concurrently receiving certain diuretics, primarily thiazides, an increased incidence of thrombocytopenia with purpura has been reported. Warfarin Monitor prothrombin time and INR It has been reported that sulfamethoxazole and trimethoprim may prolong the prothrombin time in patients who are receiving the anticoagulant warfarin (a CYP2C9 substrate). This interaction should be kept in mind when sulfamethoxazole and trimethoprim is given to patients already on anticoagulant therapy, and the coagulation time should be reassessed.
Source: FDA prescribing information (DailyMed). Set ID: c6171b62-835c-465e-905e-97f70438186e. SPL document ID: fc2caf1b-56ae-49f5-be07-f9c706b6b77a. Label effective date: September 2, 2026. Read the full label.
Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.