Ursodiol — Membership Pricing

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About Ursodiol

Ursodiol is a vital medication for managing certain gallbladder and liver conditions, including dissolving gallstones and treating specific chronic liver diseases. Navigating prescription costs can be challenging, but TheDrugClub is dedicated to making essential treatments like Ursodiol accessible and affordable. Discover how our membership can bring you significant savings and convenience on this important medication. ### What is Ursodiol and What Does It Treat? Ursodiol, also known by brand names like Actigall, Urso 250, and Urso Forte, is a naturally occurring bile acid. It's primarily prescribed for two main conditions: dissolving certain types of gallstones and treating Primary Biliary Cholangitis (PBC), a chronic liver disease. For gallstones, ursodiol is particularly effective for cholesterol-rich gallstones in patients who are not candidates for surgery or prefer a non-surgical approach. It's important to note that it doesn't work for calcified gallstones. For PBC, ursodiol is a cornerstone treatment, helping to improve liver function and slow disease progression. ### How Does Ursodiol Work? Ursodiol works by changing the composition of bile in your body. When taken orally, it's absorbed and then incorporated into your bile. This modified bile helps to reduce the amount of cholesterol produced by the liver and also decreases the absorption of cholesterol from the intestines. As a result, the bile becomes less saturated with cholesterol, making it easier for cholesterol gallstones to gradually dissolve over time. For PBC, ursodiol helps to improve the flow of bile from the liver, reducing the accumulation of toxic bile acids and protecting liver cells from damage. ### Typical Costs of Ursodiol

The cost of ursodiol can vary significantly depending on whether you purchase the generic or brand-name version, the dosage, the quantity, and the pharmacy you use. Without insurance, generic ursodiol can still range from tens to hundreds of dollars for a month's supply. Brand-name versions can be considerably more expensive, often reaching several hundred dollars or more per month. These costs can be a significant burden for individuals who rely on this medication long-term, especially if they have high deductibles or limited prescription coverage. That's why we've designed our membership program to provide unparalleled savings on essential medications like ursodiol.

The information above is for educational purposes only and does not constitute medical advice. Consult your healthcare provider before making medication decisions.

What Ursodiol is approved for (FDA label)

1. Ursodiol capsules are indicated for patients with radiolucent, noncalcified gallbladder stones < 20 mm in greatest diameter in whom elective cholecystectomy would be undertaken except for the presence of increased surgical risk due to systemic disease, advanced age, idiosyncratic reaction to general anesthesia, or for those patients who refuse surgery. Safety of use of ursodiol capsules beyond 24 months is not established. 2. Ursodiol capsules are indicated for the prevention of gallstone formation in obese patients experiencing rapid weight loss.

Source: Read the full FDA label on DailyMed. Label effective date: July 27, 2026.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Adverse reactions for Ursodiol (FDA label)

The nature and frequency of adverse experiences were similar across all groups. The following tables provide comprehensive listings of the adverse experiences reported that occurred with a 5% incidence level To report SUSPECTED ADVERSE REACTIONS, Contact AvKARE at 1-855-361-3993 or go to www.avkare.com or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. 1 1 Postmarketing Experience The following adverse reactions, presented by system organ class in alphabetical order, have been identified during post-approval use of ursodiol. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Gastrointestinal disorders : enteroliths (bezoars).

Source: FDA prescribing information (DailyMed). Set ID: 5693d709-e894-0144-e063-6294a90a99db. SPL document ID: 5797b1d5-e686-ba35-e063-6294a90adae6. Label effective date: July 27, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Contraindications for Ursodiol (FDA label)

1. Ursodiol will not dissolve calcified cholesterol stones, radiopaque stones, or radiolucent bile pigment stones. Hence, patients with such stones are not candidates for ursodiol therapy. 2. Patients with compelling reasons for cholecystectomy including unremitting acute cholecystitis, cholangitis, biliary obstruction, gallstone pancreatitis, or biliary-gastrointestinal fistula are not candidates for ursodiol therapy. 3. Allergy to bile acids.

Source: FDA prescribing information (DailyMed). Set ID: 5693d709-e894-0144-e063-6294a90a99db. SPL document ID: 5797b1d5-e686-ba35-e063-6294a90adae6. Label effective date: July 27, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Drug interactions for Ursodiol (FDA label)

Bile acid sequestering agents such as cholestyramine and colestipol may interfere with the action of ursodiol by reducing its absorption. Aluminum-based antacids have been shown to adsorb bile acids in vitro and may be expected to interfere with ursodiol in the same manner as the bile acid sequestering agents. Estrogens, oral contraceptives, and clofibrate (and perhaps other lipid-lowering drugs) increase hepatic cholesterol secretion, and encourage cholesterol gallstone formation and hence may counteract the effectiveness of ursodiol.

Source: FDA prescribing information (DailyMed). Set ID: 5693d709-e894-0144-e063-6294a90a99db. SPL document ID: 5797b1d5-e686-ba35-e063-6294a90adae6. Label effective date: July 27, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.