Tramadol-Acetaminophen — Discount Pricing

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About Tramadol-Acetaminophen

Tramadol Acetaminophen is a combination medication prescribed for moderate to moderately severe pain. This powerful duo works together to provide effective relief, helping you manage discomfort and improve your quality of life. At TheDrugClub, we understand the importance of affordable medication. Our program is designed to help members save on prescriptions like Tramadol Acetaminophen, making your healthcare more accessible.

Tramadol Acetaminophen is a prescription medication commonly used to treat moderate to moderately severe pain. It's a combination product, meaning it contains two active ingredients: tramadol and acetaminophen. This dual approach helps to tackle pain from different angles, often providing more comprehensive relief than either ingredient alone.

How Tramadol Acetaminophen Works

Each component of this medication plays a distinct role. Tramadol is an opioid-like pain reliever. It works in the brain by changing how your body feels and responds to pain. Specifically, it binds to mu-opioid receptors and also inhibits the reuptake of norepinephrine and serotonin, which are neurotransmitters involved in pain pathways. Acetaminophen, on the other hand, is a non-opioid pain reliever and fever reducer. While its exact mechanism isn't fully understood, it's believed to reduce the production of prostaglandins in the brain, which are chemicals that contribute to pain and inflammation. By combining these two medications, Tramadol Acetaminophen offers a synergistic effect, providing potent pain relief.

What It Treats

This medication is primarily prescribed for acute (short-term) or chronic (long-term) pain that is moderate to moderately severe. This can include pain from injuries, surgical procedures, or chronic conditions like osteoarthritis. It's important to use this medication exactly as prescribed by your doctor due to the presence of tramadol, which can be habit-forming.

Typical Costs and TheDrugClub Savings

The cost of Tramadol Acetaminophen can vary significantly depending on several factors, including the dosage, quantity, the pharmacy you choose, and your geographical location. As a generic medication, it's generally more affordable than brand-name alternatives. Without insurance, the cash price can range from about $15 to $50 or more for a typical prescription, but these are just estimates and can fluctuate widely.

The information above is for educational purposes only and does not constitute medical advice. Consult your healthcare provider before making medication decisions.

What Tramadol-Acetaminophen is approved for (FDA label)

Tramadol hydrochloride and acetaminophen tablets are indicated for the management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. Limitations of Use Tramadol hydrochloride and acetaminophen tablets are indicated for short-term use of five days or less. Because of the risks of addiction, abuse, misuse overdose, and death, which can occur at any dosage or duration and persist over the course of therapy [see Warnings and Precautions (5.1) ] , reserve opioid analgesics, including tramadol hydrochloride and acetaminophen tablets,foruse in patients for whom alternative treatment options are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain.

Source: Read the full FDA label on DailyMed. Label effective date: June 30, 2026.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Boxed warning for Tramadol-Acetaminophen (FDA label)

WARNING: SERIOUS AND LIFE-THREATENING RISKS FROM USE OF TRAMADOL HYDROCHLORIDE and ACETAMINOPHEN Addiction, Abuse, and Misuse Because the use of tramadol hydrochloride and acetaminophen exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death, assess each patient’s risk prior to prescribing and reassess all patients regularly for the development of these behaviors and conditions [see Warnings and Precautions (5.1) ]. Life-Threatening Respiratory Depression Serious, life-threatening, or fatal respiratory depression may occur with use of tramadol hydrochloride and acetaminophen, especially during initiation or following a dosage increase. To reduce the risk of respiratory depression, proper dosing and titration of tramadol hydrochloride and acetaminophen are essential [see Warnings and Precautions (5.2) ]. Accidental Ingestion Accidental ingestion of even one dose of tramadol hydrochloride and acetaminophen, especially by children, can result in a fatal overdose of tramadol [see Warnings and Precautions (5.2) ]. Risks From Concomitant Use With Benzodiazepines Or Other CNS Depressants Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death.

Source: FDA prescribing information (DailyMed). Set ID: cb05d615-918d-8104-e053-2995a90aa96b. SPL document ID: 557cc094-ec63-7cbe-e063-6294a90adf6c. Label effective date: June 30, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Dosage forms and strengths for Tramadol-Acetaminophen (FDA label)

Tramadol hydrochloride and acetaminophen tablets USP each contain 37.5 mg of tramadol hydrochloride USP and 325 mg of acetaminophen USP. The tablets are light yellow, capsule shaped, biconvex film-coated debossed with “I90” on one side and plain on the other side. Tablets: tramadol hydrochloride 37.5 mg and acetaminophen 325 mg. ( 3 )

Source: FDA prescribing information (DailyMed). Set ID: cb05d615-918d-8104-e053-2995a90aa96b. SPL document ID: 557cc094-ec63-7cbe-e063-6294a90adf6c. Label effective date: June 30, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Adverse reactions for Tramadol-Acetaminophen (FDA label)

The following serious adverse reactions are discussed, or described in greater detail, in other sections: Addiction, Abuse, and Misuse [see Warnings and Precautions (5.1) ] Life-Threatening Respiratory Depression [see Warnings and Precautions (5.2) ] Ultra-Rapid Metabolism of Tramadol and Other Risk Factors for Life-threatening Respiratory Depression in Children [see Warnings and Precautions (5.6) ] Neonatal Opioid Withdrawal Syndrome [see Warnings and Precautions (5.4) ] Hepatotoxicity [see Warnings and Precautions (5.9) ] Interactions with Benzodiazepines or Other CNS Depressants [see Warnings and Precautions (5.3) ] Opioid-Induced Hyperalgesia and Allodynia [See Warnings and Precautions (5.8) ] Serotonin Syndrome [see Warnings and Precautions (5.10) ] Seizures [see Warnings and Precautions (5.11) ] Suicide [see Warnings and Precautions (5.12) ] Adrenal Insufficiency [see Warnings and Precautions (5.14) ] Severe Hypotension [see Warnings and Precautions (5.15) ] Gastrointestinal Adverse Reactions [see Warnings and Precautions (5.18) ] Hypersensitivity Reactions [see Warnings and Precautions (5.19) ] Withdrawal [see Warnings and Precautions (5.21) ] The most common incidence of treatment-emergent adverse events (≥3.0%) in patients from clinical trials were constipation, diarrhea, nausea, somnolence, anorexia, dizziness, and sweating increased. ( 6 ) To report SUSPECTED ADVERSE REACTIONS, contact Aurobindo Pharma USA, Inc. at 1-866-850-2876 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

Source: FDA prescribing information (DailyMed). Set ID: cb05d615-918d-8104-e053-2995a90aa96b. SPL document ID: 557cc094-ec63-7cbe-e063-6294a90adf6c. Label effective date: June 30, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Contraindications for Tramadol-Acetaminophen (FDA label)

Tramadol hydrochloride and acetaminophen tablets are contraindicated for: all children younger than 12 years of age [see Warnings and Precautions (5.6) ] post-operative management in children younger than 18 years of age following tonsillectomy and/or adenoidectomy [see Warnings and Precautions (5.6) ] . Tramadol hydrochloride and acetaminophen tablets are also contraindicated in patients with: Significant respiratory depression [see Warnings and Precautions (5.2) ] . Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment [see Warnings and Precautions (5.13) ] . Patients with known or suspected gastrointestinal obstruction, including paralytic ileus [see Warnings and Precautions (5.18) ] . Previous hypersensitivity to tramadol, acetaminophen, any other component of this product, or opioids [see Warnings and Precautions (5.19) ] . Concurrent use of monoamine oxidase inhibitors (MAOIs) or use within the last 14 days [see Drug Interactions (7) ] . Children younger than 12 years of

Source: FDA prescribing information (DailyMed). Set ID: cb05d615-918d-8104-e053-2995a90aa96b. SPL document ID: 557cc094-ec63-7cbe-e063-6294a90adf6c. Label effective date: June 30, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Warnings and precautions for Tramadol-Acetaminophen (FDA label)

Opioid-Induced Hyperalgesia and Allodynia : Opioid-Induced Hyperalgesia (OIH) occurs when an opioid analgesic paradoxically causes an increase in pain, or an increase in sensitivity to pain. If OIH is suspected, carefully consider appropriately decreasing the dose of the current opioid analgesic, or opioid rotation. ( 5.8 ) Serotonin Syndrome : May be life-threatening. Can occur with use of tramadol alone, with concomitant use of serotonergic drugs, with drugs that impair metabolism of serotonin or tramadol. ( 5.10 ) Risk of Seizure : Can occur at the recommended dose of tramadol. Concomitant use with other drugs may increase seizure risk.

Source: FDA prescribing information (DailyMed). Set ID: cb05d615-918d-8104-e053-2995a90aa96b. SPL document ID: 557cc094-ec63-7cbe-e063-6294a90adf6c. Label effective date: June 30, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.