Estradiol — Discount Pricing

Other medications in Hormones

• Fludrocortisone
• Letrozole
• Medroxyprogesterone
• Norethindrone
• Octreotide
• Progesterone
• Tamoxifen
• Testosterone Cypionate

About Estradiol

Estradiol is a widely prescribed medication, primarily used as a form of estrogen hormone replacement. It plays a crucial role in managing various conditions, from menopausal symptoms to preventing osteoporosis. At TheDrugClub, we believe essential medications like estradiol should be affordable and accessible. Our members enjoy significant savings, including $0 co-pays and free home delivery on many common prescriptions.

The information above is for educational purposes only and does not constitute medical advice. Consult your healthcare provider before making medication decisions.

What Estradiol is approved for (FDA label)

Estradiol vaginal cream, USP, 0.01% is indicated in the treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause.

Source: Read the full FDA label on DailyMed. Label effective date: August 28, 2026.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Boxed warning for Estradiol (FDA label)

WARNING: ENDOMETRIAL CANCER, CARDIOVASCULAR DISORDERS, BREAST CANCER and PROBABLE DEMENTIA Estrogen-Alone Therapy Endometrial Cancer There is an increased risk of endometrial cancer in a woman with a uterus who uses unopposed estrogens. Adding a progestin to estrogen therapy has been shown to reduce the risk of endometrial hyperplasia, which may be a precursor to endometrial cancer. Adequate diagnostic measures, including directed or random endometrial sampling when indicated, should be undertaken to rule out malignancy in postmenopausal women with undiagnosed persistent or recurring abnormal genital bleeding [see WARNINGS , Malignant Neoplasms , Endometrial Cancer ]. Cardiovascular Disorders and Probable Dementia Estrogen-alone therapy should not be used for the prevention of cardiovascular disease or dementia [see CLINICAL STUDIES and WARNINGS , Cardiovascular Disorders , and Probable Dementia ]. The Women’s Health Initiative (WHI) estrogen-alone substudy reported increased risks of stroke and deep vein thrombosis (DVT) in postmenopausal women (50 to 79 years of age) during 7.1 years of treatment with daily oral conjugated estrogens (CE) [0.625 mg]-alone,relative to placebo [see CLINICAL STUDIES and WARNINGS , Cardiovascular Disorders ]. The WHI Memory Study (WHIMS) estrogen-alone ancillary study of WHI reported an increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 5.2 years of treatment with daily CE (0.625 mg) -alone, relative to placebo.

Source: FDA prescribing information (DailyMed). Set ID: c8a2d29c-299c-4559-b859-87b303a4af81. SPL document ID: 61484e03-f4f1-4e80-b7f0-b0b1ce5a7866. Label effective date: August 28, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.

Contraindications for Estradiol (FDA label)

Estradiol vaginal cream, USP, 0.01% should not be used in women with any of the following conditions: 1. Undiagnosed abnormal genital bleeding. 2. Known, suspected, or history of cancer of the breast. 3. Known or suspected estrogen-dependent neoplasia. 4. Active DVT, PE or history of these conditions. 5. Active arterial thromboembolic disease (for example, stroke, MI) or a history of these conditions. 6. Known anaphylactic reaction or angioedema to estradiol vaginal cream, USP, 0.01%. 7. Known liver dysfunction or disease. 8. Known protein C, protein S, or antithrombin deficiency, or other known thrombophilic disorders. 9. Known or suspected pregnancy.

Source: FDA prescribing information (DailyMed). Set ID: c8a2d29c-299c-4559-b859-87b303a4af81. SPL document ID: 61484e03-f4f1-4e80-b7f0-b0b1ce5a7866. Label effective date: August 28, 2026. Read the full label.

Excerpt from the FDA-approved prescribing information. This is not medical advice; talk to your doctor or pharmacist.